Microarray comparative genomic hybridization in prenatal diagnosis: a review
نویسندگان
چکیده
منابع مشابه
Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies
OBJECTIVE To demonstrate the usefulness of microarray testing in prenatal diagnosis based on our laboratory experience. METHODS Prenatal samples received from 2004 to 2011 for a variety of indications (n = 5003) were tested using comparative genomic hybridization-based microarrays targeted to known chromosomal syndromes with later versions of the microarrays providing backbone coverage of the...
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Microarray-based comparative genomic hybridization (array CGH) is a newly emerged molecular cytogenetic technique for rapid evaluation of the entire genome with sub-megabase resolution. It allows for the comprehensive investigation of thousands and millions of genomic loci at once and therefore enables the efficient detection of DNA copy number variations (a.k.a, cryptic genomic imbalances). Th...
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Comparative genomic hybridization was used to compare genetic diversity of five strains of Leptospira (Leptospira interrogans serovars Bratislava, Canicola, and Hebdomadis and Leptospira kirschneri serovars Cynopteri and Grippotyphosa). The array was designed based on two available sequenced Leptospira reference genomes, those of L. interrogans serovar Copenhageni and L. interrogans serovar Lai...
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Cytogenetic analysis is a crucial tool of prenatal diagnosis. The ability to rapidly detect aneuploidy and identify small structural abnormalities of foetal chromosomes has been greatly improved by the use of molecular cytogenetic technologies. Microarray-based Comparative Genomic Hybridization (aCGH) has been recently employed in postnatal diagnosis of cryptic chromosomal aberrations, but use ...
متن کاملA survey of genomic diversity in Enterococcus faecalis by microarray based comparative 1 genomic hybridization 2
1 We have compared nine Enterococcus faecalis strains with E. faecalis V583 (V583), for 2 which a complete genome sequence and a genome-wide microarray is available. The strains 3 we have used in this study (the test strains) originated from various environments; 4 veterinarian, food, and environmental isolates, as well as lab strains. Comparative genomic 5 hybridization using microarrays (CGH)...
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ژورنال
عنوان ژورنال: Ultrasound in Obstetrics & Gynecology
سال: 2012
ISSN: 0960-7692
DOI: 10.1002/uog.11180